Ukulimala Kwezinzwa Zokubona-02

Ukwelashwa Kwamaseli E-Stem Kokulimala Kwezinzwa Zokubona: Isimangaliso Sokuphinde Ubone

Ebuchwephesheni bezokwelapha obuthuthuka ngokushesha banamuhla, izifo eziningi ezazibhekwa njengezingelapheki manje zibona ithemba elisha. Namuhla, sabelana ngendaba ethinta inhliziyo mayelana nokwelashwa kwe-mesenchymal stem cell (MSC) yokulimala kwe-optic nerve, indlela yokwelapha eletha ithemba elisha lokubona ezigulini eziningi.

Indaba kaMnu. Zhang

UMnu. Zhang, oneminyaka engu-47 ubudala, ungunjiniyela ozinikele. Kodwa-ke, impilo yakhe yashintsha kakhulu ezinyangeni ezine ezedlule ngenxa yengozi enkulu yemoto. Kule ngozi, uMnu. Zhang walimala kakhulu emthanjeni wakhe wangakwesokudla, okwabangela ukwehla okusheshayo kokubona kwaze kwaba ukubona ukukhanya okuncane. Naphezu kokwelashwa kwendabuko ngama-steroids kanye nemithi ye-neurotrophic, umbono wakhe wabonisa ukuthuthuka okuncane. Lesi simo samkhathaza kakhulu yena nomndeni wakhe.

Ngemva kokunconywa ngumngane, uMnu. Zhang wezwa ngokwelashwa okusha—ukwelashwa ngamaseli e-mesenchymal stem. Ngemva kokubonisana okuningiliziwe nodokotela abangochwepheshe nokuqonda ngokugcwele inqubo yokwelapha, uMnu. Zhang wanquma ukuzama le ndlela entsha.

Amaseli okuqala atholakala egazini le-umbilical cord lamavolontiya anempilo, ahlolwa ngokucophelela futhi andiswa ekukhuleni ukuze abe namandla okuvuselela nokulungisa anamandla. Lawa maseli okuqala afakwa ngokujova ngaphakathi kwe-optic nerve sheath, alethwa ngqo esweni likaMnu. Zhang lokunene ukuze kukhuthazwe ukuvuselelwa kwe-optic nerve eyonakele.

Inqubo yokwelashwa yenziwa endaweni engenamagciwane ukuqinisekisa ukuphepha nokunemba kuzo zonke izinyathelo. Phakathi nesonto lokuqala ngemuva kokuhlinzwa, uMnu. Zhang wabhekana nokuvuvukala okuncane kanye nokungakhululeki endaweni yomjovo, ngaphandle kwezinye izimpawu ezimbi. Kodwa-ke, ngokumangazayo, ekupheleni kwenyanga yokuqala ngemuva kokuhlinzwa, uMnu. Zhang waqala ukubona ukukhanya okuncane futhi wakwazi ukubona ukukhanya okukhanyayo. Lolu shintsho lwamgcwalisa ngethemba lesikhathi esizayo.

Ezinyangeni ezalandela, umbono kaMnu. Zhang wathuthuka kancane kancane. Ngenyanga yesithathu, wayekwazi ukubona ukunyakaza kwezinto ezinkulu, kanti ukuhlolwa kwe-visual evoked potential (VEP) kwabonisa ukululama okukhulu komsebenzi wokuhambisa imizwa ye-optic. Ngenyanga yesithupha, umbono wakhe wesokudla wawuzinzile cishe ngo-0.15, okwamenza wakwazi ukuhlukanisa amafonti amakhulu nezimo ezilula, okuthuthukisa kakhulu ikhwalithi yokuphila kwakhe kwansuku zonke.

Ukululama kukaMnu. Zhang akusho nje ukunqoba kwezokwelapha zanamuhla kodwa futhi kuwubufakazi bemizamo ehlangene yabacwaningi bezokwelapha abaningi kanye nezisebenzi zokuzithandela. Amaseli okuqala e-Mesenchymal, ngokukhishwa kwezinto ezahlukahlukene zokukhula kanye nama-cytokine, asize ekuvuseleleni nasekululameni kokusebenza kwe-optic nerve eyonakele. Le ndlela yokwelapha ikhombisa amandla amakhulu, inikeza ithemba ezigulini eziningi ezinjengoMnu. Zhang.