Kukuvara kwetsinga dzemaziso-02

Kurapa Masero Emuviri Pakukuvara Kwetsinga Dzemaziso: Chishamiso Chekuonazve

Muhunyanzvi hwekurapa huri kufambira mberi nekukurumidza nhasi, zvirwere zvakawanda zvaimboonekwa sezvisingarapiki zvava kuona tariro itsva. Nhasi, tiri kugovera nyaya inobaya mwoyo nezvekurapa kwemesenchymal stem cell (MSC) yekukuvara kwetsinga dzemaziso, nzira yekurapa inounza tariro itsva yekuona kune varwere vakawanda.

Nyaya yaVaZhang

VaZhang, vane makore makumi mana nemanomwe ekuberekwa, iinjiniya akazvipira. Zvisinei, hupenyu hwavo hwakachinja zvakanyanya mwedzi mina yapfuura nekuda kwetsaona yemotokari yakakomba. Mutsaona iyi, VaZhang vakakuvara zvakanyanya kutsinga yavo yerudyi, zvikaita kuti vaone zvishoma nezvishoma chiedza chisati chanyatsooneka. Pasinei nekurapwa kwetsika nemishonga yesteroid neneurotrophic, kuona kwavo hakuna kunyatsochinja. Mamiriro ezvinhu aya akavanetsa zvikuru ivo nemhuri yavo.

Vachikurudzirwa neshamwari, VaZhang vakaziva nezvekurapa kuri kutanga—kurapa nemasero emesenchymal. Mushure mekubvunzana zvakadzama navanachiremba vane hunyanzvi uye kunzwisisa zvizere maitiro ekurapa, VaZhang vakasarudza kuedza nzira itsva iyi.

Masero aya akawanikwa kubva muropa remudumbu remunhu ane hutano hwakanaka, akaongororwa zvakasimba uye akawedzerwa mukurima kuti ave nemasimba ekugadzirisa uye ekugadzirisa. Akapihwa nejekiseni remukati metsinga dzemaziso, masero aya aiendeswa zvakananga muziso rekurudyi raVaZhang kuti vabatsire pakuvandudzwa kwetsinga dzemaziso dzakakuvara.

Kurapwa kwacho kwakaitwa munzvimbo isina utachiona kuitira kuti pave nechokwadi chekuti murwere akachengeteka uye akarurama padanho rega rega. Muvhiki yekutanga mushure mekuvhiyiwa, VaZhang vakazvimba zvishoma uye kusanzwa zvakanaka panzvimbo yavakabayiwa jekiseni, pasina zvimwe zviratidzo zvakaipa. Zvisinei, zvinoshamisa kuti pakupera kwemwedzi wekutanga mushure mekuvhiyiwa, VaZhang vakatanga kuona chiedza chisina kujeka uye vaigona kuona chiedza chakajeka. Kuchinja uku kwakavazadza netariro yeramangwana.

Mumwedzi yakatevera, kuona kwaVaZhang kwakavandudzika zvishoma nezvishoma. Pakazosvika mwedzi wechitatu, vakakwanisa kuona mafambiro ezvinhu zvikuru, uye bvunzo dzekuona dzakaratidza kuti zvinhu zvikuru zvava kugona kuona (VEP) dzakaratidza kupora kukuru kwebasa re optic nerve conduction. Pakazosvika mwedzi wechitanhatu, kuona kweziso ravo rekurudyi kwakanga kwagadzikana ne 0.15, zvichivabatsira kusiyanisa mafonti makuru nemaumbirwo akareruka, zvichiwedzera zvikuru kunaka kwehupenyu hwavo hwezuva nezuva.

Kupora kwaVaZhang hakungorevi kukunda kwemishonga yemazuva ano chete asiwo humbowo hwekushanda pamwe chete kwevaongorori vezvekurapa nevazvipiri vakawanda. Masero eMesenchymal stem, kuburikidza nekuburitswa kwezvinhu zvakasiyana-siyana zvinokura uye ma cytokines, akabatsira patsva uye kupora kwetsinga yemaziso yakakuvara. Nzira iyi yekurapa inoratidza kugona kukuru, ichipa tariro kuvarwere vazhinji vakaita saVaZhang.