Izindaba Zenkampani

Ucwaningo oluqavile luqokomisa ukusebenza kahle okumangalisayo kokwelashwa kwamaseli e-CAR-T ekwelapheni i-B-cell Acute Lymphoblastic Leukemia (B-ALL). Ucwaningo, oluhilela ukubambisana ne-BIOOCUS kanye ne-Lu Daopei Hospital, lubonisa intuthuko ebalulekile, lubeka ukwelashwa njengendlela yokwelapha ebalulekile.

Abacwaningi baseLu Daopei Hospital kanye nabalingani bamazwe ngamazwe bahlola izindlela zokwelapha ze-CAR-T cell ezisezingeni eliphezulu, benikeza ithemba ezigulini ezine-B cell monoancies. Lolu cwaningo luqokomisa intuthuko ekwakhiweni nasekusetshenzisweni, lubonisa imiphumela ethembisayo kanye namathuba okusha esikhathini esizayo.

Izifundo zemitholampilo zakamuva zembula ukuthi amaseli e-CD19 CAR-T asekelwe ku-4-1BB abonisa ukusebenza kahle okuphezulu kokulwa nomdlavuza uma kuqhathaniswa namaseli e-CAR-T asekelwe ku-CD28 ekwelapheni i-acute lymphoblastic leukemia (r/r B-ALL) ephinde yabuya noma engaphikisi.

Ucwaningo lwakamuva eSibhedlela iLu Daopei lubonise ukusebenza kahle nokuphepha okuphezulu kokwelashwa kwamaseli e-CD19 CAR-T ngemithamo ephansi ekwelapheni iziguli ze-B acute lymphoblastic leukemia (B-ALL) eziphinde zagula noma eziphinde zagula. Ucwaningo, olwaluhlanganisa iziguli ezingu-51, lubonise izinga elimangalisayo lokuphulukiswa okuphelele kanye nemiphumela emibi emincane.

Isibhedlela iLu Daopei kanye neHebei Senlang Biotechnology bamemezele imiphumela ethembisayo evela ocwaningweni lwabo lwakamuva mayelana nokuphepha nokusebenza kahle kokwelashwa kwe-CAR-T kwe-B cell leukemia ebukhali. Lokhu kubambisana kugqamisa amandla emiklamo emisha yamaseli e-CAR-T yokuthuthukisa imiphumela yeziguli.

Ucwaningo olusha oluholwa nguDkt. Zhi-tao Ying wasePeking University Cancer Hospital lubonise ukuphepha nokusebenza kahle kokwelashwa kwamaseli e-IM19 CAR-T ekwelapheni umdlavuza we-B-cell ophinde wabuyela emuva futhi ongasasebenzi. Kushicilelwe ku- Ijenali YaseShayina Yezidakamizwa Ezintsha, ucwaningo lubika ukuthi iziguli ezingu-11 kwezingu-12 zithole ukuphulukiswa okuphelele ngaphandle kwemiphumela emibi kakhulu, okubonisa amandla e-IM19 njengendlela yokwelapha ethembisayo yeziguli ezinezinye izindlela ezilinganiselwe.

Ukuqeqeshwa Kwaminyaka Yonke Kwango-2024 Kokuphathwa Kwegazi Emtholampilo kanye Nobuchwepheshe Bokudluliswa Kwegazi eSanhe City kuqhutshwe ngempumelelo eSibhedlela iYanda Ludaopei. Lo mcimbi uhlose ukuthuthukisa ukuphathwa kwegazi emtholampilo kanye nokuphepha kokudluliswa kwegazi ngezifundo ezibanzi ezihanjelwe ochwepheshe bezempilo abangaphezu kwe-100 abavela ezikhungweni ezahlukene zezokwelapha.

Ukuqinisekisa ukuthi iziguli ezine-leukemia zithola ukwelashwa okuphephile nokukhululekile kuhilela ukunakekelwa kwansuku zonke ngokucophelela, okuhlanganisa ukuhlanzeka kwemvelo, inhlanzeko yomuntu siqu, ukudla okunempilo, kanye nokuzivocavoca okufanele. Lo mhlahlandlela unikeza amathiphu abalulekile okunakekelwa kwansuku zonke okuphumelelayo ukusekela ukululama.

Ucwaningo lwamuva nje luqokomisa ukusebenza kahle nokuphepha kokwelashwa kwamaseli e-NS7CAR-T ekwelapheni i-T-cell acute lymphoblastic leukemia (R/R T-ALL) ephinde yabuya noma engaphikisiwe kanye ne-T-cell lymphoblastic lymphoma (R/R T-LBL). Lokhu kwelashwa kunikeza ithemba elisha ezigulini ezinalezi zinhlobo zomdlavuza ezinolaka.

Ingqungquthela Yonyaka Ye-12 Ye-Lu Daopei Hematology kulindeleke ukuthi ibe khona kusukela mhla zingama-23 kuya ku-24 kuNcwaba, 2024, e-Beijing International Convention Center. Joyina nathi ukuze uthole izingxoxo ezinolwazi kanye nentuthuko yakamuva kwe-hematology.

Ucwaningo lwesigaba sokuqala lwe-CD7 CAR-T lwe-R/R AML olwenziwe yiqembu likaDaopei Lu luqala ukusebenza e-ASHUMhlangano Waminyaka Yonke wama-65 we-American Society of Hematology (ASH) ubanjelwe ungaxhunyiwe ku-inthanethi (eSan Diego, e-USA) naku-inthanethi ngoDisemba 9-12, 2023. Izazi zethu zenze umbukiso omuhle kakhulu ngale nhlanganisela...

I-American Society of Hematology (ASH) ingumhlangano wezemfundo ophezulu emkhakheni we-hematology emhlabeni jikelele. Iqiniso lokuthi iSibhedlela iLu Daopei sikhethwe njengowokugcina we-ASH iminyaka elandelanayo libonisa ngokugcwele impumelelo yaso kwezemfundo...