Indaba Yesiguli: I-B-ALL Eyingozi Kakhulu, Ukufakelwa Umongo Wethambo Ezinyangeni Eziyi-9, Eminyakeni Emibili Kamuva—Isiqalo Esinempilo Somlwi Osemusha
Ezinyangeni zokuqala zokuphila, uShuo Shuo (igama elingelona elakhe) wabhekana nokuxilongwa okungekho mntwana okufanele akubekezelele. Esenezinyanga ezine nje kuphela ubudala, watholakala enesifo esiyingozi kakhulu i-Acute B Lymphoblastic Leukemia (B-ALL) esine-MLL-AF4 gene fusion, enye yezinhlobo eziyinselele kakhulu nezinolaka ze-leukemia yezingane.
Ukuxilongwa kwatholakala ngemuva kokuvakashela esibhedlela ngenxa yokuminyana kwamakhala, lapho ukuhlolwa kwegazi lakhe kwabonisa khona izinombolo ezesabekayo—inani lamangqamuzana amhlophe egazi likhuphuka ku-480×10^9/L, i-hemoglobin ku-72g/L, kanye nama-platelet ku-39×10^9/L. Lezi zimpawu zazikhomba ukuphazamiseka okukhulu kwegazi, futhi umndeni wakhe, ukhathazekile kakhulu, wafuna ngokushesha ukunakekelwa okukhethekile eSibhedlela iYanda Lu Daopei.
Ngemva kokuhlolwa okwengeziwe, isimo sikaShuo Shuo saqinisekiswa njenge-MLL-AF4 positive B-ALL, uhlobo lwe-leukemia oluyingozi kakhulu ezinganeni ezincane. Ngenxa yobudala bakhe kanye nokugula kwakhe okunamandla, odokotela batusa ukufakelwa i-stem cell ukuze banikeze ithuba elihle kakhulu lokululama.
UDkt. Wei Zhijie, uMqondisi woMnyango Wokufakelwa Kwamathambo esibhedlela iYanda Lu Daopei, kanye nethimba lakhe bakha uhlelo lokwelapha oluphelele. NgoMeyi 2022, uShuo Shuo wathola uhlelo lokwelashwa ngamakhemikhali olwaholela ekuphumuleni okuphelele. Ngemva kwalokho, wenziwa i-consolidation chemotherapy ukuqinisekisa ukuthi i-leukemia ihlala ilawulwa. Phakathi nalesi sikhathi, ithimba lezokwelapha laqhubeka nokuxhumana nomndeni ukuze liqaphe isimo sakhe eduze.
Ngo-Agasti 2022, uShuo Shuo, manje osekhululekile ngokuphelele, waphumelela ukufakelwa iseli legazi elingaphansi kwe-hematopoietic elingelona elihlobene. Inqubo yahamba kahle, lapho amangqamuzana akhe amhlophe egazi nama-platelet efakwe emavikini amabili nezinsuku eziyisikhombisa ngemuva kokufakelwa, ngokulandelana. I-bone marrow biopsy elandelayo yaqinisekisa ukuthi awekho amangqamuzana abulalayo, futhi wafinyelela i-100% chimerism ngezinga lezakhi zofuzo ze-MLL-AF4 elingu-0%. Ukufakelwa kwaba yimpumelelo, futhi amathuba kaShuo Shuo okukhululwa isikhathi eside athuthuke kakhulu.
Nokho, uhambo lokufakelwa isitho lwalunezinselele. UShuo Shuo wabhekana nesifo esibi nesingapheli se-graft-versus-host (GVHD), esathinta isikhumba sakhe. Ithimba lezokwelapha lalungisa ngokushesha imithi yakhe, futhi ngokunakekelwa kwabo ngenkuthalo, amaqhubu aqala ukuphela, futhi isimo sakhe sonke sathuthuka kancane kancane.
Namuhla, uShuo Shuo useneminyaka emibili nezinyanga ezintathu ngemuva kokufakelwa i-leukemia. I-leukemia yakhe isalokhu ilungile, futhi usefinyelele ingqophamlando enkulu: ukuqala i-kindergarten! Umndeni wakhe ugcwele ithemba njengoba bembona eqina nsuku zonke.
Ngokuzikhandla, isibindi, kanye nokungaguquguqukiEsekela ithimba lakhe lezokwelapha, uShuo Shuo ukulungele ukwamukela ikusasa, egcwele ukumamatheka, ukuhleka, kanye nenjabulo yobuntwana.