Ibali lesigulana: I-B-ALL enobungozi obukhulu, ukufakelwa kweBone Marrow kwiinyanga ezili-9, kwiminyaka emibini kamva—isiqalo esisempilweni somlwi oselula
Kwiinyanga zokuqala zobomi bakhe, uShuo Shuo (igama elingelolakhe) wajongana nokuxilongwa okungekho mntwana ufanele ukuba akunyamezela. Eneenyanga ezine kuphela ubudala, wafunyaniswa ukuba une-Acute B Lymphoblastic Leukemia (B-ALL) enobungozi obuphezulu ene-MLL-AF4 gene fusion, enye yezona ndlela zinzima nezinobundlongondlongo ze-leukemia yabantwana.
Ukuxilongwa kwakhe kwenzeke emva kokutyelela esibhedlele ngenxa yokuxinana kweempumlo, apho uvavanyo lwakhe lwegazi lubonise amanani axhalabisayo—inani leeseli ezimhlophe zegazi linyuka kwi-480×10^9/L, i-hemoglobin kwi-72g/L, kunye neeplatelets kwi-39×10^9/L. Ezi mpawu zazibonisa ingxaki enkulu yegazi, kwaye usapho lwakhe, luxhalabile kakhulu, lwafuna unyango olukhethekileyo kwiSibhedlele saseYanda Lu Daopei.
Emva kokuhlolwa ngakumbi, imeko kaShuo Shuo yaqinisekiswa njenge-MLL-AF4 positive B-ALL, uhlobo lwe-leukemia olunobungozi obukhulu kwiintsana. Ngenxa yobudala bakhe kunye nobunzima bokugula kwakhe, oogqirha bacebisa ukufakelwa i-stem cell ukuze kunike ithuba elihle lokuchacha.
UGqr. Wei Zhijie, uMlawuli weSebe lokuTshintshela kwiSibhedlele iYanda Lu Daopei, kunye neqela lakhe baphuhlise isicwangciso sonyango esibanzi. NgoMeyi 2022, uShuo Shuo wafumana irejimeni yekhemotherapi eyakhokelela ekuphumleni ngokupheleleyo. Emva koko, wenziwa ikhemotherapi yokuqinisa ukuqinisekisa ukuba i-leukemia ihlala ilawulwa. Ngeli xesha, iqela lezonyango laqhubeka nokunxibelelana rhoqo nosapho ukuze lijonge imeko yakhe ngokusondeleyo.
Ngo-Agasti 2022, uShuo Shuo, ngoku ekhululekile ngokupheleleyo, waphumelela ukufakelwa iseli ye-hematopoietic stem cell engahlobene nomnikelo. Inkqubo yahamba kakuhle, iiseli zakhe ezimhlophe zegazi kunye neeplatelets zifakelwe kwiiveki ezimbini neentsuku ezisixhenxe emva kokufakelwa, ngokulandelelana. I-bone marrow biopsy elandelayo yaqinisekisa ukuba akukho ziseli zinobungozi, kwaye wafumana i-100% chimerism ngenqanaba le-MLL-AF4 gene level ye-0%. Ukufakelwa kube yimpumelelo, kwaye amathuba kaShuo Shuo okukhululwa ixesha elide aphucuke kakhulu.
Nangona kunjalo, uhambo lokufakelwa isitho lwaluneengxaki. UShuo Shuo wafumana isifo esibuhlungu nesingapheliyo se-graft-versus-host (GVHD), esachaphazela ulusu lwakhe. Iqela lezonyango lalungisa amayeza akhe ngokukhawuleza, kwaye ngononophelo lwabo olukhutheleyo, amaqhuqhuva aqala ukuphela, kwaye imeko yakhe iyonke yaphucuka ngokuthe ngcembe.
Namhlanje, uShuo Shuo uneminyaka emibini neenyanga ezintathu emva kokufakelwa umntwana. I-leukemia yakhe isalungile, kwaye ufikelele kwinqanaba elibalulekileyo: ukuqala isikolo sabantwana abancinci! Usapho lwakhe luzele lithemba njengoko bembona ekhula eqina yonke imihla.
Ngokuqina, inkalipho, kunye nokungaguquguqukiNgenxa yenkxaso yeqela lakhe lezonyango, uShuo Shuo ukulungele ukwamkela ikamva, ezele luncumo, ukuhleka, kunye novuyo lobuntwana.