Kukosha kwekiriniki kweOligoclonal Protein Bands Mushure meBCMA CAR-T Therapy muVarwere Vakawanda veMyeloma
Kunzwisisa Mabhendi eOligoclonal Protein muCAR-T Therapy
Mukati Multiple Myeloma (MM), kuvapo kwemapuroteni asina kujairika (APB), anozivikanwawo seoligoclonal protein bands, kwakaonekwa mushure mekuisirwa masero eropa. Zvisinei, kuwanda kwavo uye kukosha kwavo mukurapa muvarwere vanowana BCMA-targeted CAR-T cell therapy hazvisati zvajeka. Kuti vagadzirise izvi, vaongorori vanobva kuSecond Affiliated Hospital yeXi'an Jiaotong University vakaita ongororo yekudzokera shure kuti vaongorore kuitika kweAPB, subtypes, uye kukosha kwekufanotaura muvarwere veMM vanorapwa neLCAR-B38M sechikamu chePhase 1 LEGEND-2 trial. Zvakawanikwa zvakaburitswa munguva pfupi yapfuura muHemaSphere, inotungamirwa naMapurofesa He Aili, Wang Fangxia, naBai Ju.
Zvakawanikwa Zvikuru
Chidzidzo ichi chakaongorora varwere makumi mana nemanomwe, uye 23 (48.9%) vakatanga APB mushure mekurapwa neCAR-T. Rudzi rwakanyanya kuwanda rwaive IgG (91.3%). Nguva yepakati yekutanga kweAPB yaive mwedzi 3.6 mushure mekuisirwa CAR-T, uye nguva yepakati yaive mwedzi 5.8. Chinokosha ndechekuti, kuitika kweAPB kwakabatana nemhinduro dzakasimba dzekurapwa, kurarama kwenguva refu pasina progression (PFS), uye kuvandudzwa kwehupenyu hwese (OS).
Mamwe mashoko aisanganisira:
- Migumisiro Yekiriniki Yakavandudzwa: Varwere vane APB vakaratidza kuti vari nani pakupindura kurapwa kweLCAR-B38M uye vakawana kupora kwakadzama.
- Kuvandudzwa Kwekupora Kwemasoja Emuviri: Varwere veAPB vakaratidza mwero wepamusoro wekupora kwema immunoglobulins nema lymphocytes mushure memwedzi mitatu nemitanhatu mushure mekurapwa, zvichiratidza mhinduro dzakasimba dzehumoral immune system uye mushure mezvo kuumbwazve kwedziviriro yemuviri.
- Zviratidzo zveKufanotaura: Kuongororwa kwemultivariate kwakaratidza kushanda kweCAR-T therapy, kuwanda kwemaplatelet, kuvapo kweAPB, uye mazinga eβ2-microglobulin sezvinhu zvakazvimiririra zvinofanotaura PFS. Kune OS, kushanda kweCAR-T uye kuwanda kwemaplatelet ndizvo zvinhu zvakazvimiririra.
Zvinofadza kuti chidzidzo ichi hachina kuwana mutsauko wakakosha mumapoka eT-cell kana NK-cell pakati pemapoka eAPB neesiri eAPB, zvichiratidza kuti kukosha kweAPB kunogona kubva mukupora kwemasero emuviri uye immune system panzvimbo pemaitiro emasero ekudzivirira chirwere.
Mhedziso uye Zvazvinoreva
Chidzidzo ichi chinosimbisa kuti kuvapo kweAPB mushure mekurapwa neBCMA CAR-T kunoenderana nekurerukirwa kwakadzama uye mhedzisiro iri nani yekiriniki muvarwere vane MM vakadzokera shure/vasingachabatike. Pamusoro pezvo, zvakawanikwa zvinoratidza kuti APB inogona kuva chiratidzo chekupora kwemuviri mushure mekurapwa, zvichivhura nzira dzekuwedzera kutsvagurudza mukuvandudza kurapwa kweCAR-T uye kunzwisisa simba rekugadzirisa muviri.
Sezvo nzira dzekurapa dzeCAR-T dzinotungamirirwa neBCMA dzichiri kuramba dzichichinja, ruzivo rwakadaro runokosha mukuvandudza nzira dzekurapa nekuvandudza mhedzisiro yevarwere veMM pasi rese.