Qhov Tseem Ceeb ntawm Kev Kho Mob ntawm Oligoclonal Protein Bands Tom Qab BCMA CAR-T Therapy rau Cov Neeg Mob Multiple Myeloma

Kev Nkag Siab Txog Oligoclonal Protein Bands Hauv Kev Kho Mob CAR-T
Nyob rau hauv Ntau yam mob myeloma (MM), qhov muaj cov protein bands tsis zoo (APB), tseem hu ua oligoclonal protein bands, tau pom tom qab kev hloov pauv hlwb hematopoietic. Txawm li cas los xij, lawv qhov zaus thiab qhov tseem ceeb hauv kev kho mob hauv cov neeg mob uas tau txais BCMA-targeted CAR-T cell therapy tseem tsis meej. Txhawm rau daws qhov teeb meem no, cov kws tshawb fawb los ntawm Second Affiliated Hospital ntawm Xi'an Jiaotong University tau ua ib txoj kev tshawb fawb rov qab los tshuaj xyuas qhov tshwm sim ntawm APB, subtypes, thiab qhov tseem ceeb ntawm kev kwv yees hauv cov neeg mob MM kho nrog LCAR-B38M ua ib feem ntawm Theem 1 LEGEND-2 kev sim. Cov kev tshawb pom tau luam tawm tsis ntev los no hauvHemaSphere, coj los ntawm Xib Fwb He Aili, Wang Fangxia, thiab Bai Ju.

Cov Ntsiab Lus Tseem Ceeb

Txoj kev tshawb fawb no tau soj ntsuam 47 tus neeg mob, nrog rau 23 (48.9%) tau tsim APB tom qab kev kho mob CAR-T. Hom kab mob feem ntau yog IgG (91.3%). Lub sijhawm nruab nrab rau APB pib yog 3.6 lub hlis tom qab CAR-T infusion, thiab lub sijhawm nruab nrab yog 5.8 lub hlis. Qhov tseem ceeb, APB tshwm sim tau cuam tshuam nrog kev teb kho mob zoo dua, kev ciaj sia ntev dua yam tsis muaj kev nce qib (PFS), thiab kev ciaj sia tag nrho zoo dua (OS).

Cov kev pom ntxiv suav nrog:

• Cov Txiaj Ntsig Zoo Dua Hauv Kev Kho MobCov neeg mob uas muaj APB tau qhia tias muaj kev teb zoo dua rau kev kho mob LCAR-B38M thiab tau txais kev zam txim ntau dua.
• Kev Txhim Kho Kev Tiv Thaiv Kab Mob Zoo DuaCov neeg mob APB tau pom tias muaj kev rov zoo dua ntawm cov immunoglobulins thiab lymphocytes ntawm 3 thiab 6 lub hlis tom qab kev kho mob, qhia txog kev teb ntawm lub cev tiv thaiv kab mob zoo thiab kev rov tsim kho lub cev tiv thaiv kab mob tom qab.
• Cov Cim Qhia Txog Kev Kwv YeesKev tshuaj xyuas ntau yam tau pom tias CAR-T kev kho mob zoo, cov ntshav platelet suav, APB muaj, thiab β2-microglobulin theem ua cov yam ntxwv ywj pheej rau kev kwv yees PFS. Rau OS, CAR-T kev ua tau zoo thiab cov ntshav platelet suav yog cov yam ntxwv ywj pheej.

Qhov txaus siab yog, txoj kev tshawb fawb no tsis pom muaj qhov sib txawv tseem ceeb hauv T-cell lossis NK-cell subpopulations ntawm APB thiab cov pab pawg tsis yog APB, qhia tias APB tus nqi kwv yees feem ntau yuav yog los ntawm kev txhim kho humoral thiab kev tiv thaiv kab mob dua li cov txheej txheem tiv thaiv kab mob ntawm tes.

Xaus Lus thiab Qhov Cuam Tshuam

Daim ntawv tshawb fawb no qhia meej tias qhov muaj APB tom qab kev kho mob BCMA CAR-T muaj feem cuam tshuam nrog kev rov zoo dua thiab cov txiaj ntsig zoo dua hauv cov neeg mob MM uas rov qab mob/tsis kho tau. Tsis tas li ntawd xwb, cov kev tshawb pom qhia txog APB ua lub cim qhia txog kev rov zoo ntawm lub cev tiv thaiv kab mob tom qab kev kho mob, qhib txoj hauv kev rau kev tshawb fawb ntxiv txog kev kho CAR-T kom zoo dua thiab nkag siab txog kev rov qab kho lub cev tiv thaiv kab mob.

Raws li kev kho mob CAR-T uas tsom mus rau BCMA txuas ntxiv hloov zuj zus, cov kev nkag siab zoo li no muaj txiaj ntsig zoo rau kev txhim kho cov txheej txheem kho mob thiab txhim kho cov txiaj ntsig rau cov neeg mob MM thoob ntiaj teb.