Cov Txiaj Ntsig Zoo Kawg Nkaus ntawm CD7-Targeted CAR-T Therapy rau T-ALL thiab T-LBL
Tsis ntev los no, kev sim tshuaj kho mob tau ua pov thawj tias muaj kev vam meej ntau hauv kev kho mob T-cell acute lymphoblastic leukemia (T-ALL) thiab T-cell lymphoblastic lymphoma (T-LBL) uas rov qab mob dua lossis tsis kho tau siv CD7-targeted chimeric antigen receptor (CAR) T cell therapy. Txoj kev tshawb fawb no, uas tau ua los ntawm pab neeg los ntawm Hebei Yanda Lu Daopei Tsev Kho Mob thiab Lu Daopei Institute of Hematology, tau koom nrog 60 tus neeg mob uas tau txais ib koob tshuaj ntawm cov tshuaj anti-CD7 CAR (NS7CAR) T cell uas xaiv los ntawm ntuj.
Cov txiaj ntsig ntawm kev sim siab yeej txhawb siab heev. Txog hnub 28, 94.4% ntawm cov neeg mob tau txais kev zam txim tag nrho (CR) hauv cov pob txha. Tsis tas li ntawd, ntawm 32 tus neeg mob uas muaj kab mob extramedullary, 78.1% tau qhia tias muaj kev teb zoo, nrog rau 56.3% tau txais kev zam txim tag nrho thiab 21.9% tau txais kev zam txim ib nrab. Cov feem pua ntawm kev ciaj sia nyob ob xyoos thiab cov nqi ciaj sia tsis muaj kev nce qib yog 63.5% thiab 53.7%, raws li.
Txoj kev kho mob tshiab no yog qhov tseem ceeb rau nws txoj kev nyab xeeb uas tswj tau, nrog rau kev tso tawm cytokine tshwm sim hauv 91.7% ntawm cov neeg mob (feem ntau yog qib 1/2), thiab neurotoxicity pom hauv 5% ntawm cov neeg mob. Ntxiv mus, kev tshawb fawb pom tias cov neeg mob uas tau txuas ntxiv nrog kev hloov pauv consolidation tom qab ua tiav CR muaj cov neeg muaj sia nyob tsis muaj kev nce qib ntau dua piv rau cov neeg uas tsis tau ua.
Peb lub tuam txhab kuj tseem tab tom tshawb nrhiav lub peev xwm ntawm CD7 CAR-T cell therapy nrog peb cov khoom lag luam, lub hom phiaj yog los pab txhawb kev kho mob rau T-cell malignancies.
Cov kev tshawb pom no qhia txog lub peev xwm ntawm CD7-targeted CAR-T cell therapy los muab kev cia siab tshiab rau cov neeg mob uas muaj T-ALL thiab T-LBL uas tsis kho tau lossis rov qab mob, uas yog ib qho tseem ceeb hauv kev sib ntaus sib tua tiv thaiv cov kab mob nyuaj no.