Ngā Hua Hou o te Whakaora CAR-T i Whaiarohia e te CD7 mō te T-ALL me te T-LBL

Kua whakaatuhia e tētahi whakamātautau haumanu tata nei ngā whanaketanga nui i roto i te maimoatanga o te mate pukupuku toto nui (T-ALL) me te mate pukupuku toto nui (T-LBL) kua hoki whakamuri, kua ātete rānei ki te mate pukupuku toto nui mā te whakamahi i te rongoā pūtau-T CD7-targeted chimeric antigen receptor (CAR). Ko te rangahau, i whakahaerehia e tētahi tīma mai i te Hōhipera o Hebei Yanda Lu Daopei me te Whare Wānanga o Hematology o Lu Daopei, i uru atu ki te 60 ngā tūroro i whiwhi i te horopeta kotahi o ngā pūtau-T anti-CD7 CAR (NS7CAR) kua tīpakohia ā-taiao.

He tino whakatenatena ngā hua o te whakamātautau. I te rā 28, 94.4% o ngā tūroro i tutuki te murunga hōhonu katoa (CR) i roto i te hinu wheua. Hei tāpiri, i roto i ngā tūroro 32 me te mate extramedullary, 78.1% i whakaatu i te urupare pai, me te 56.3% i tutuki te murunga katoa me te 21.9% i tutuki te murunga hapa. Ko ngā reiti oranga whānui mō ngā tau e rua me te oranga kore-haere ko te 63.5% me te 53.7%, ia.

He mea whakamiharo tēnei rongoā auaha mō tōna āhua haumaru ka taea te whakahaere, me te mate tukunga cytokine e pā ana ki te 91.7% o ngā tūroro (ko te nuinga he taumata 1/2), ā, i kitea te paitini roro i roto i te 5% o ngā take. I tua atu, i kitea e te rangahau he nui ake te tere ora kore-whakamua o ngā tūroro i haere tonu me ngā whakawhitinga whakakotahi i muri i te whakatutukitanga o te CR i ērā kāore i pērā.

Kei te tūhuratia hoki e tā mātou kamupene te pūmanawa o te rongoā pūtau CD7 CAR-T me tā mātou hua motuhake, me te whai kia whai wāhi atu ki te whakatairanga i ngā maimoatanga mō ngā mate pukupuku pūtau-T.

E whakaatu ana ēnei kitenga i te kaha o te rongoā pūtau CAR-T e arotahi ana ki te CD7 ki te tuku tumanako hou mō ngā tūroro he T-ALL me te T-LBL uaua, he mate urutā rānei, he tohu nui tēnei i roto i te pakanga tonu ki ēnei mate uaua.