Zotsatira Zodabwitsa za Chithandizo cha CAR-T Choyang'aniridwa ndi CD7 cha T-ALL ndi T-LBL
Kafukufuku waposachedwapa wasonyeza kupita patsogolo kwakukulu pa chithandizo cha matenda a T-cell acute lymphoblastic leukemia (T-ALL) omwe abwereranso kapena kukana matenda ndi T-cell lymphoblastic lymphoma (T-LBL) pogwiritsa ntchito chithandizo cha maselo a T a CD7-targetted chimeric antigen receptor (CAR). Kafukufukuyu, wochitidwa ndi gulu lochokera ku Hebei Yanda Lu Daopei Hospital ndi Lu Daopei Institute of Hematology, adakhudza odwala 60 omwe adalandira mlingo umodzi wa maselo a T otsutsana ndi CD7 CAR (NS7CAR) omwe adasankhidwa mwachibadwa.
Zotsatira za mayesowa ndi zolimbikitsa kwambiri. Pofika tsiku la 28, 94.4% ya odwala adapeza chikhululukiro chathunthu (CR) mu mafupa. Kuphatikiza apo, pakati pa odwala 32 omwe anali ndi matenda a extramedullary, 78.1% adawonetsa kuti ali ndi vuto, ndipo 56.3% adapeza chikhululukiro chathunthu ndi 21.9% adapeza chikhululukiro chapang'ono. Chiwerengero cha kupulumuka kwa zaka ziwiri komanso kupulumuka kopanda kupita patsogolo chinali 63.5% ndi 53.7%, motsatana.
Chithandizo chatsopanochi n'chodziwika bwino chifukwa cha chitetezo chake chodalirika, pomwe cytokine release syndrome imapezeka mwa odwala 91.7% (makamaka giredi 1/2), ndipo poizoni wa mitsempha amapezeka mwa odwala 5%. Kuphatikiza apo, kafukufukuyu adapeza kuti odwala omwe adapitiliza ndi opaleshoni yolimbitsa thupi atakwanitsa CR anali ndi chiwopsezo chachikulu cha kupulumuka popanda kupita patsogolo poyerekeza ndi omwe sanachite.
Kampani yathu ikufufuzanso kuthekera kwa chithandizo cha maselo a CD7 CAR-T pogwiritsa ntchito mankhwala athu apadera, cholinga chake ndikuthandizira kupititsa patsogolo chithandizo cha khansa ya T-cell.
Zomwe zapezekazi zikugogomezera kuthekera kwa chithandizo cha maselo a CAR-T choyang'aniridwa ndi CD7 kuti chipereke chiyembekezo chatsopano kwa odwala omwe ali ndi T-ALL ndi T-LBL omwe sagwira ntchito bwino kapena omwe abwereranso kuchipatala, zomwe zikuwonetsa kufunika kwakukulu pankhondo yolimbana ndi matenda ovuta awa.