He Rangahau Whanui i Whakaputaina ki roto i te Blood: Te Rongoā CD7 CAR-T e Hangai Ana ki te Nanobody mō te Acute Myeloid Leukemia
Kua tino angitu te Rōpū Hauora o Lu Daopei i roto i te mara o te toto. I raro i te kaiārahi a Tākuta Lu Peihua, ko tā rātou rangahau hou, "He Paturopi Chimeric kua Whiriwhiria ā-Taiao e ahu mai ana i te Nanobody-CVD7 kua Whāia" Pūtau-T Kaiwhakawhiwhi "Te rongoā mō te mate pukupuku myeloid acute", i whakaputaina tata nei i roto i te hautaka rongonui o te ao Toto (Tauwehe Pānga: 21). E whakaatu ana tēnei rangahau i tētahi huarahi auaha ki te rongoā i te mate pukupuku myeloid acute (AML), e whakaatu ana i te whai huatanga me te haumaru o te patu pukupuku, me te whakarato hoki i te tumanako hou mō ngā tūroro he AML kua hoki mai, he uaua rānei ki te mate (R/R).
Huarahi Auaha
Ko te rangahau te kaihautū o te whakamahinga o ngā pūtau CD7 CAR-T e ahu mai ana i te nanobody i roto i te rongoā AML. Ko ngā rongoā CAR-T tuku iho e whakamahi ana i ngā kongakonga taurangi mekameka kotahi (scFv) i ahu mai i ngā paturopi monoclonal (mAbs). I whakamahia e tēnei rangahau ngā nanobodies—ngā paturopi rohe kotahi i ahu mai i ngā paturopi mekameka taumaha camelid. Nā te iti o te rahi (15kDa ki te whakataurite ki te 150kDa IgG tangata) me te iti o te ārai mate, ka whakaratohia e ngā nanobodies te motuhaketanga pai rawa atu o te antigen me te hononga here me te whakaiti i ngā pānga taha.
I whakaatuhia e te NS7CAR-T e ahu mai ana i te nanobody te whai huatanga me te haumaru o te ārai-puku i roto i ngā whakamātautau haumanu me ngā whakamātautau haumanu. I whakaatuhia e ngā hua haumanu te tipu pūtau me te mahi ārai-puku pai ake i te whakataurite ki ngā pūtau CAR-T e ahu mai ana i te scFv. I tua atu, i roto i te whakamātautau haumanu Wāhanga I, i tutuki i te maimoatanga he 70% te reiti murunga katoa i waenga i te 10 ngā tūroro AML CD7-pai, me te 60% i eke ki te mana iti rawa o te mate toenga (MRD)-kino.
Pānga Hauora
I whakaurua ki te whakamātautau ngā tūroro he nui te mōrearea, tae atu ki te hunga kua whakawhiti pūtau take hematopoietic o mua (allo-HSCT) me te maha o ngā momo rongoā. Ahakoa ēnei wero, i tutuki i te rongoā NS7CAR-T e ahu mai ana i te nanobody ngā hua pai me ngā pānga taha ka taea te whakahaere, tae atu ki te cytokine release syndrome ngawari (CRS) i roto i te 80% o ngā kaiuru. Kāore i kitea he take o te paitini neuro.
Ngā Aronga ā-Mārama
E whakaatu ana te rangahau i te hiahia mō ngā whakamātautau nunui ake hei whakamana i te whai huatanga me te haumaru o te rongoā CD7 CAR-T e ahu mai ana i te nanobody i roto i te maimoatanga AML. E whakaatu ana hoki i ngā wero pēnei i te ngaronga o te antigen CD7, he arai nui tonu tēnei i roto i ngā kēhi ka hoki anō ki te mate. Ko te aro atu ki ēnei take te mea nui ki te arotau i te rongoā mō ngā tono haumanu whānui.
He Pae Hou mō te Maimoatanga AML
Ko te AML, he mate pukupuku toto tino uaua, he rerekē hoki, kua roa nei e wero ana i te whakatutuki i te murunga pumau me te whakapai ake i ngā reiti oranga whānui. Ko te auahatanga i whakaurua mai e te Rōpū Hauora o Lu Daopei, ehara i te mea he huarahi rongoā hou mō ngā tūroro engari he whakakaha anō hoki i tō rātou hiranga mātauranga i roto i te rangahau toto o te ao.
He tohu tēnei tohu nui mō te whakapau kaha o te tīma ki te hono i ngā rangahau matatau me ngā mahi haumanu. I a te tīma e haere tonu ana ki te tūhura i ngā maimoatanga hou, ka kawea mai e ā rātou mahi he tumanako hou ki ngā tūroro o te ao, ā, ka whakatakoto i te ara mō ngā whanaketanga whakarerekētanga i roto i te hematology.