Ubushakashatsi bwakozwe mu bigo byinshi bwerekanye ko hari ingaruka nziza ku barwayi ba kanseri y'amaraso barimo guterwa MTUD Allogeneic Stem Cell Transplantation na ATG
Ubushakashatsi bwakorewe mu Bushinwa bushingiye ku nzego nyinshi bwagaragaje ibisubizo bishimishije byo guteranya uturemangingo tw’amaraso dudafite aho duhuriye (MMUD) allogeneic hematopoietic stem cells (allo-HSCT) ku barwayi bafite kanseri y’amaraso. Gutera Umwobo w'Amagufwa, ubu bushakashatsi busuzuma akamaro ko guhuza MMUD allo-HSCT na antithymocyte globulin (ATG) mu gukumira indwara ya graft-versus-host (GVHD). Ubu buryo bwagaragaje ko butanga ibisubizo bikomeye ku buvuzi, nubwo hari itandukaniro riri hagati y’utanga n’uhabwa antigen ya leukocyte (HLA) mu buryo butari bwo.
Ubushakashatsi bwakorewe ku barwayi 211 bafite imyaka 14 cyangwa irenga, bose bagaragayeho kanseri y’amaraso kandi bari bamaze koroherwa burundu mbere yo guterwa. Abarwayi bagabanyijwemo amatsinda abiri hashingiwe ku mubare w’impinduka za HLA: Itsinda rya A rifite impagarara imwe y’allele n’Itsinda rya B rifite impagarara ebyiri cyangwa zirenze. Abarwayi bose bahawe uturemangingo tw’amaraso two mu gice cyo ku ruhande rw’umubiri ndetse n’ubuvuzi bwo kuvura hakoreshejwe uburyo bwo gusukura uturemangingo, hamwe no kwirinda GVHD hakoreshejwe ATG.
Ibisubizo by'ingenzi birimo igipimo cyo hejuru cyo gukwirakwizwa kwa GVHD mu maraso cya 96.2% kuri neutrophils na 93.4% kuri platelets mu minsi 28 ya mbere. Ubushakashatsi bwagaragaje kandi ko umubare muto w'abantu barwaye GVHD ikomeye cyane, aho GVHD yo mu cyiciro cya III-IV igaragara muri 12.3% by'abanduye, naho GVHD idakira yo mu cyiciro cya kabiri kugeza ku gikomeye igera kuri 21% nyuma y'imyaka itatu. Igipimo cy'imyaka itatu yo kubaho (OS) cyari 63.1%, naho igipimo cy'ubuzima butagira indwara (DFS) kikaba 54.5%.
Ibyavuye mu bushakashatsi byagaragaje kandi ko umubare w’ibibazo bya HLA utari uhuye cyane nta ngaruka zikomeye ku mubare w’abarokotse, ku kwiyongera kwa GVHD, cyangwa kongera gukora kwa virusi. Byongeye kandi, gukoresha dose nke ya ATG (≤6 mg/kg) byazamuye igipimo cyo gutera indwara kandi bitanga inyungu mu buvuzi bitagize ingaruka ku mubare w’abarokotse cyangwa abasubira inyuma, bitanga uburyo bwo kuvura buhendutse.
Ubu bushakashatsi ni bwo bushakashatsi bunini bwakozwe mu Bushinwa ku bijyanye na MMUD allo-HSCT kandi bugaragaza ubushobozi bw'ubu buryo bwo gutera intanga ku barwayi ba kanseri y'amaraso ishobora gutera intanga. Butanga ubumenyi bw'ingirakamaro mu kunoza umusaruro w'abarwayi no kunoza uburyo bwo gutera intanga, bigatuma bigira uruhare runini mu bijyanye n'amaraso. Ubuvuzi bwa kanseri.