Na Mekhoa ea Kalafo ea Lisele ke Bokamoso ba Lefu la Autoimmune?
Kalafo e nchafalitsoeng bakeng sa kankere e ka boela ea khona ho phekola le ho tsosolosa sesole sa 'mele ho fana ka phomolo ea nako e telele kapa mohlomong le ho phekola tse itseng. Mafu a ho Itšireletsa 'Meleng.
Kalafo ea lisele tsa T tsa Chimeric antigen receptor (CAR) e fane ka mokhoa o mocha oa ho phekola mofetše oa mali ho tloha ka 2017, empa ho na le matšoao a pele a hore li-immunotherapy tsena tsa sele li ka sebelisoa hape bakeng sa mafu a autoimmune a bakoang ke lisele tsa B.
Ka Loetse selemong se fetileng, bafuputsi ba Jeremane ba tlalehile hore bakuli ba bahlano ba nang le refractory systemic lupus erythematosus (SLE) ba phekoloang ka kalafo ea CAR T-cell kaofela ba fihletse phomolo ntle le meriana. Nakong ea phatlalatso, ha ho bakuli ba neng ba khutletse morao ho fihlela likhoeling tse 17 kamora kalafo. Bangoli ba hlalositse seroconversion ea li-antibodies tsa antinuclear ho bakuli ba babeli ba nang le tlhahlobo e telele ka ho fetisisa, "ba bontša hore ho hlakoloa ha li-clone tsa B-cell tse ikemetseng ho ka lebisa tokisong e pharaletseng ea autoimmune," bafuputsi ba ngola.
Phuputsong e 'ngoe ea nyeoe e phatlalalitsoeng ka Phuptjane, bafuputsi ba sebelisitse lisele tsa CAR-T tse shebaneng le CD-19 ho phekola monna ea lilemo li 41 ea nang le refractory antisynthetase syndrome ea nang le progressive myositis le interstitial lung disease. Likhoeli tse tšeletseng kamora kalafo, ho ne ho se na matšoao a myositis ho MRI 'me CT scan ea sefuba e bontšitse ho khutlela morao ka botlalo ha alveolitis.
Ho tloha ka nako eo, lik'hamphani tse peli tsa biotechnology - Cabaletta Bio e Philadelphia le Kyverna Therapeutics e Emeryville, California - li se li filoe maemo a potlakileng ho tsoa ho US Food and Drug Administration bakeng sa kalafo ea CAR T-cell bakeng sa SLE le lupus nephritis. Bristol-Myers Squibb le eona e ntse e etsa teko ea mohato oa 1 ho bakuli ba nang le SLE e matla, e sa laoleheng. Lik'hamphani tse 'maloa tsa biotechnology le lipetlele Chaena le tsona li etsa liteko tsa kliniki bakeng sa SLE. Empa ena ke ntlha feela ea leqhoa mabapi le mekhoa ea phekolo ea lisele bakeng sa lefu la autoimmune, ho boletse Max Konig, MD, PhD, moprofesa ea thusang oa bongaka lefapheng la ramatiki Sekolong sa Bongaka sa Univesithi ea Johns Hopkins se Baltimore.
"Ke nako e thabisang haholo. Ha ho mohla e kileng ea e-ba teng historing ea autoimmune," o boletse joalo.
"Ho Qala Bocha" bakeng sa Sistimi ea 'Mele ea ho Sireletsa ...
Mekhoa ea phekolo e shebaneng le lisele tsa B e bile teng ho tloha mathoasong a lilemo tsa bo-2000 ka meriana e kang rituximab, moriana oa antibody oa monoclonal o shebaneng le CD20, e leng antigen e hlahang holim'a lisele tsa B. Lisele tsa CAR T tse fumanehang hona joale li shebane le antigen e 'ngoe ea holim'a lisele, CD19, 'me ke phekolo e matla haholo. Ka bobeli li sebetsa hantle ho fokotseng lisele tsa B maling, empa lisele tsena tsa T tse entsoeng ka boqapi tse shebaneng le CD19 li ka fihla liseleng tsa B tse lutseng liseleng ka tsela eo mekhoa ea phekolo ea antibody e ke keng ea e khona, Konig o hlalositse.