Cov Kev Kho Mob Cellular puas yog Yav Tom Ntej ntawm Kab Mob Autoimmune?

Ib txoj kev kho mob tshiab rau mob qog noj ntshav kuj tseem yuav kho tau thiab rov pib dua lub cev tiv thaiv kab mob kom rov zoo mus sij hawm ntev lossis tej zaum yuav kho tau qee yam mob. Cov Kab Mob Autoimmune.

Txij li xyoo 2017 los, kev kho mob Chimeric antigen receptor (CAR) T-cell tau muab txoj hauv kev tshiab los kho cov mob qog ntshav, tab sis muaj cov cim qhia thaum ntxov tias cov kev kho mob cellular immunotherapies no tuaj yeem rov siv dua rau cov kab mob autoimmune B-cell.

Thaum lub Cuaj Hlis xyoo tas los, cov kws tshawb fawb hauv lub teb chaws Yelemees tau tshaj tawm tias tsib tus neeg mob uas muaj tus kab mob refractory systemic lupus erythematosus (SLE) kho nrog CAR T-cell therapy txhua tus tau txais kev zam txim yam tsis muaj tshuaj. Thaum lub sijhawm tshaj tawm, tsis muaj tus neeg mob rov qab mob dua txog li 17 lub hlis tom qab kev kho mob. Cov kws sau ntawv tau piav qhia txog seroconversion ntawm cov tshuaj antinuclear hauv ob tus neeg mob uas muaj kev saib xyuas ntev tshaj plaws, "qhia tias kev tshem tawm ntawm cov clones autoimmune B-cell yuav ua rau muaj kev kho mob autoimmune dav dua," cov kws tshawb fawb sau.

Hauv lwm qhov kev tshawb fawb uas tau luam tawm thaum Lub Rau Hli, cov kws tshawb fawb tau siv CD-19 tsom rau CAR-T hlwb los kho ib tug txiv neej hnub nyoog 41 xyoo uas muaj tus kab mob refractory antisynthetase syndrome nrog rau mob myositis zuj zus thiab mob interstitial ntsws. Rau lub hlis tom qab kev kho mob, tsis muaj cov cim qhia ntawm myositis ntawm MRI thiab kev ntsuas CT hauv siab qhia tau tias muaj kev rov qab tag nrho ntawm alveolitis.

Txij thaum ntawd los, ob lub tuam txhab biotechnology - Cabaletta Bio hauv Philadelphia thiab Kyverna Therapeutics hauv Emeryville, California - twb tau txais kev tso cai sai los ntawm US Food and Drug Administration rau kev kho mob CAR T-cell rau SLE thiab lupus nephritis. Bristol-Myers Squibb kuj tseem tab tom ua qhov kev sim theem 1 rau cov neeg mob uas muaj SLE hnyav, tsis kho tau. Ntau lub tuam txhab biotechnology thiab tsev kho mob hauv Suav teb kuj tseem tab tom ua qhov kev sim tshuaj rau SLE. Tab sis qhov no tsuas yog qhov kawg ntawm lub pob zeb khov kho txog kev kho mob cellular rau tus kab mob autoimmune, Max Konig, MD, PhD, tus pab xibfwb ntawm kev kho mob hauv kev faib rheumatology ntawm Johns Hopkins University School of Medicine hauv Baltimore tau hais.

"Nws yog lub sijhawm zoo siab heev. Nws tsis tau muaj dua li hauv keeb kwm ntawm kev tiv thaiv kab mob autoimmunity," nws hais.

Ib qho "Reboot" rau Lub Cev Tiv Thaiv Kab Mob

Cov kev kho mob uas tsom rau B-cell tau muaj txij li thaum xyoo 2000s nrog cov tshuaj xws li rituximab, ib qho tshuaj monoclonal antibody uas tsom rau CD20, ib qho antigen uas qhia tawm ntawm qhov chaw ntawm B cell. Cov CAR T cell tam sim no muaj tsom rau lwm qhov antigen ntawm qhov chaw, CD19, thiab yog kev kho mob muaj zog dua. Ob qho tib si muaj txiaj ntsig zoo ntawm kev ua kom cov B cell hauv cov ntshav ploj mus, tab sis cov CD19-targeted T cell no tuaj yeem ncav cuag B cell uas zaum hauv cov ntaub so ntswg hauv txoj kev uas cov tshuaj antibody tsis tuaj yeem ua tau, Konig piav qhia.