Kurapa Kwemasero Inguva Yemberi Yezvirwere Zvemuviri Zvinozvidzivirira Here?
Kurapa gomarara nenzira itsva kunogona zvakare kurapa nekugadzirisa masoja emuviri kuti ape zororo kwenguva refu kana kutorapa mamwe marudzi egomarara. Zvirwere zveAutoimmune.
Kurapa kweT-cell neChimeric antigen receptor (CAR) kwave nemaitiro matsva ekurapa kenza yeropa kubvira muna 2017, asi pane zviratidzo zvekutanga zvekuti immunotherapy idzi dzinogona kushandiswazve pazvirwere zve autoimmune zvinokonzerwa neB-cell.
MunaGunyana wegore rapfuura, vaongorori vekuGermany vakashuma kuti varwere vashanu vane refractory systemic lupus erythematosus (SLE) vakarapwa neCAR T-cell therapy vese vakawana zororo risina mishonga. Panguva yekuburitswa kwayo, hapana varwere vakanga vadzokera kuchirwere kwemwedzi inosvika gumi neminomwe mushure mekurapwa. Vanyori vakatsanangura seroconversion ye antinuclear antibodies muvarwere vaviri vakatevera kwenguva refu, "zvichiratidza kuti kubviswa kwe autoimmune B-cell clones kunogona kutungamira mukugadziriswa kwakanyanya kwe autoimmune immunity," vaongorori vanonyora.
Mune imwe nyaya yakaburitswa muna Chikumi, vaongorori vakashandisa masero eCAR-T akanangana neCD-19 kurapa murume ane makore makumi mana nerimwe ekuberekwa ane refractory antisynthetase syndrome ane progressive myositis uye interstitial lung disease. Mwedzi mitanhatu mushure mekurapwa, pakanga pasina zviratidzo zvemyositis paMRI uye chest CT scan yakaratidza kudzokera shure kwe alveolitis.
Kubva ipapo, makambani maviri e biotechnology - Cabaletta Bio muPhiladelphia neKyverna Therapeutics muEmeryville, California - atopihwa zvinzvimbo zvekukurumidza kubva kuUS Food and Drug Administration yekurapa CAR T-cell SLE ne lupus nephritis. Bristol-Myers Squibb iri kuitawo bvunzo yechikamu chekutanga muvarwere vane SLE yakaoma, isingashande. Makambani akati wandei e biotechnology nezvipatara muChina ari kuitawo bvunzo dzekiriniki dzeSLE. Asi ichi chingori chidimbu chepfungwa pamusoro pekurapa kwemasero ezvirwere zve autoimmune, akadaro Max Konig, MD, PhD, mubatsiri wepurofesa wezvekurapa muchikamu cherheumatology paJohns Hopkins University School of Medicine muBaltimore.
"Inguva inonakidza zvikuru. Hazvina kumboitika munhoroondo ye autoimmunity," akadaro.
"Kutangazve" kweSistimu yeMuviri
Mishonga inorapwa nemasero eB yave iripo kubvira pakutanga kwema2000 nemishonga yakaita serituximab, mushonga we monoclonal antibody unorwisa CD20, antigen inowanikwa pamusoro pemasero eB. Masero eCAR T aripo parizvino anotarisa imwe antigen iri pamusoro, CD19, uye mushonga une simba guru. Ose ari maviri anoshanda pakuderedza masero eB muropa, asi aya masero eT anorapwa neCD19 anogona kusvika kumasero eB akagara mumatishu nenzira isingagoneke nemishonga yeantibody, Konig akatsanangura.