He pai ake rānei ngā rongoā pūkoro mō te mate pūnaha ārai mate?

Tērā pea ka taea e tētahi maimoatanga hou mō ngā mate pukupuku te rongoā me te tautuhi anō i te pūnaha ārai mate hei whakarato i te murunga mō te wā roa, hei whakaora rānei i ētahi mate. Ngā Mate Pūnaha Ārai Mate.

Kua tukuna e te rongoā pūtau-T chimeric antigen receptor (CAR) tētahi huarahi hou ki te rongoā i ngā mate pukupuku toto mai i te tau 2017, engari kei reira ngā tohu tōmua e whakaatu ana ka taea te whakamahi anō i ēnei rongoā ārai mate pūtau mō ngā mate pūnaha ārai mate e pāngia ana e ngā pūtau-B.

I te marama o Hepetema o te tau kua hipa, i kōrero ngā kairangahau i Tiamana e rima ngā tūroro he mate pūnaha lupus erythematosus (SLE) i rongoatia ki te rongoā pūtau-T CAR i whiwhi i te murunga kore rongoā. I te wā i whakaputaina ai, kāore anō kia hoki mai anō ngā tūroro tae atu ki te 17 marama i muri i te maimoatanga. I whakaahuahia e ngā kaituhi te seroconversion o ngā paturopi antinuclear i roto i ngā tūroro e rua me te aroturukitanga roa rawa atu, "e tohu ana ko te whakakorenga o ngā tārua pūtau-B aunoa ka arahi pea ki te whakatikatika whānui ake o te mate pūnaha-aunoa," te tuhituhi a ngā kairangahau.

I roto i tētahi atu rangahau take i whakaputaina i te marama o Hune, i whakamahia e ngā kairangahau ngā pūtau CAR-T kua arotahi ki te CD-19 hei rongoā i tētahi tāne 41-tau te pakeke he mate ātete antisynthetase me te myositis haere whakamua me te mate pūkahukahu interstitial. E ono marama i muri i te maimoatanga, kāore he tohu o te myositis i runga i te MRI, ā, i whakaatuhia e te karapa CT uma te hokinga katoa o te alveolitis.

Mai i taua wā, e rua ngā kamupene hangarau koiora — a Cabaletta Bio i Philadelphia me Kyverna Therapeutics i Emeryville, California — kua whakawhiwhia ki ngā tohu tere mai i te US Food and Drug Administration mō te rongoā CAR T-cell mō te SLE me te lupus nephritis. Kei te whakahaerehia hoki e Bristol-Myers Squibb tētahi whakamātautau wāhanga 1 i roto i ngā tūroro he SLE kino, he uaua ki te rongoā. He maha ngā kamupene hangarau koiora me ngā hōhipera i Haina kei te whakahaerehia hoki ngā whakamātautau haumanu mō te SLE. Engari koinei anake te pito o te hukapapa e pā ana ki ngā rongoā pūtau mō te mate pūnaha ārai mate, e ai ki a Max Konig, MD, PhD, he ahorangi āwhina rongoā i te wehenga rheumatology i te Johns Hopkins University School of Medicine i Baltimore.

"He wā tino whakahihiri tēnei. Kāore i kitea i mua i roto i te hītori o te mate ārai mate," tana kī.

He "Whakaara Anō" mō te Pūnaha Ārai Mate

Kua whakamahia ngā rongoā e aro ana ki ngā pūtau-B mai i te tīmatanga o te tau 2000 me ngā rongoā pēnei i te rituximab, he rongoā paturopi monoclonal e aro ana ki te CD20, he antigen e whakaatuhia ana i te mata o ngā pūtau-B. Ko ngā pūtau-T CAR e wātea ana i tēnei wā e aro ana ki tētahi atu antigen mata, ko te CD19, ā, he rongoā kaha ake. He whai hua ngā mea e rua ki te whakaiti i ngā pūtau-B i roto i te toto, engari ka taea e ēnei pūtau-T e aro ana ki te CD19 te toro atu ki ngā pūtau-B e noho ana i roto i ngā kiko i tētahi ara e kore e taea e ngā rongoā paturopi, e ai ki tā Konig.