Ọrịa kansa ọbara Lymphoblastic dị oke njọ (T-ALL)-04

Onye ọrịa ahụ bụ nwoke dị afọ iri na ise, a chọpụtara na ọ nwere ọrịa leukemia T-cell acute lymphoblastic leukemia (T-ALL nwere STIL-TAL1 positivity, mkpụrụ ndụ ihe nketa na-adịghị mma) na ngwụcha Disemba 2020, a gwọkwara ya n'ụlọ ọgwụ dị n'ógbè ahụ na ọtụtụ usoro ọgwụgwọ chemotherapy oge niile iji nweta mgbaghara zuru oke. Emere ọgwụgwọ hemizygous haematopoietic stem cell nke nna-site-nwa nwoke na nwa ya na 2 June 2021, mana ọ dị mwute ikwu na achọpụtara nlọghachi nke ụmị ọkpụkpụ n'ime ọnwa atọ ka e mechachara ọgwụgwọ ahụ, otu usoro ọgwụgwọ chemotherapy enweghịkwa ike. N'otu oge ahụ, ọ malitere inwe ihu na-agbapụta na ikuku na-agbapụta, akụkụ ọnụ gbagọrọ agbagọ, na mpụta lumbar gosiri na ọrịa leukemia nke sistemu akwara etiti na-apụta.

T-ALL nwere STIL-TAL1 positive, nlọghachi mbụ mgbe a gbasasịrị allogeneic, yana leukemia sistemụ akwara etiti, bụ ikpe siri ike ịgwọ n'oge ahụ na-enweghị CAR-T. Nna nwatakịrị ahụ jụrụ ajụjụ gbasara ngalaba ọbara na Tianjin Cancer Hospital Airport Hospital site n'aka ndị enyi ya. Mgbe ha kwusịrị okwu zuru ezu, ha bịara na Tianjin Cancer Hospital Airport Hospital, na-achọ ịbanye na nnwale ahụike CAR-T dị ka mgbalị ikpeazụ.

Mkpụrụ ndụ Tumor mbụ nke CAR-T dara ada mụbara ngwa ngwa, wee tinye ndụ ya n'ihe ize ndụ.

Na 26 Ọktoba 2021, a kpọbatara onye ọrịa ahụ na ngalaba mbụ nke Ngalaba Hematology. N'ihi mmụba ngwa ngwa nke mkpụrụ ndụ kansa, onye ọrịa ahụ mere chemotherapy iji belata ibu tumor ma nata chemotherapy intrathecal. Mmiri cerebrospinal egosighi ọrịa ọ bụla fọdụrụ. Mgbe emechara ka ọ kwụsie ike, a chịkọtara lymphocytes nna ya maka ọdịbendị mkpụrụ ndụ CAR-T. Na 19 Nọvemba, a tinyere mkpụrụ ndụ CAR-T CD7 nke onye nyere onyinye n'ime onye ọrịa ahụ.

Ụbọchị ole na ole ka e tinyere ya n'ime ọgwụ ahụ, tupu mkpụrụ ndụ CAR-T agbasaa, mkpụrụ ndụ kansa ahụ mụbara ọzọ ngwa ngwa, a na-ahụkwa ọtụtụ mgbawa n'ọbara dị n'akụkụ, nke gosiri ọdịda nke ọgwụgwọ CAR-T mbụ.

N'oge a, Ụlọ Ọgwụ Tianjin Cancer Hospital Airport na-eme nnwale ahụike nke CAR-T zuru ụwa ọnụ (CD7 UCAR-T) maka ọrịa leukemia T-lymphoblastic dị egwu. Ndị nne na nna ahụ gosipụtara oke mkpa, na-ekwu na ha ga-achụso ọbụna ohere 1% maka nwa ha. Ndị otu ahụike ahụ kparịtara ụka na ezinụlọ ahụ wee kpebie ịdebanye aha onye ọrịa ahụ na nnwale ahụike CD7 UCAR-T.

Mbelata zuru oke mgbe CD7 UCAR-T gasịrị. Ugbu a ọnwa abụọ mgbe e tinyere ya n'ọrụ.

Na ụbọchị abụọ nke ọnwa Disemba, onye ọrịa ahụ natara ọgwụ mkpụrụ ndụ CD7 U-CART tinyere ọgwụgwọ mbelata ibu etuto ahụ na nlekọta nkwado. Mgbe a gwọchara ya, ọ nwetara ahụ ọkụ na ike ọgwụgwụ ogologo oge. Site na nkwado mgbochi nje na mmiri mmiri, ihe mgbaàmà ya dị mkpa kwụsiri ike ma ọnọdụ okpomọkụ ahụ dị mma.

Nnyocha e mere n'ime ụmị ọkpụkpụ na mmiri ụbụrụ n'ụbọchị nke 18 na 28 mgbe CAR-T gasịrị gosiri na e wepụrụ ya kpamkpam ma nwee mmetụta ọjọọ nke MRD. Ọnọdụ nwatakịrị ahụ ka mma nke ukwuu, ike ya laghachiri azụ, agụụ ya gbakee, nne ya—onye nwere mwute na mbụ—nwetaghachiri olileanya.

Ugbu a, onye ọrịa ahụ emeela HSCT nke abụọ nke haploidical na Tianjin Cancer Hospital Airport Hospital ma nọrọ na mgbaghara zuru oke ọnwa abụọ mgbe e tinyere ya n'ọrụ.